Biliverdin reductase isozymes in metabolism
نویسندگان
چکیده
منابع مشابه
Biliverdin-IXa Reductase and Biliverdin-IXP Reductase from Human Liver
This report describes for the first time the identification of four forms of biliverdin reductase including two biliverdin-MP reductases and two biliverdin-Ma reductases, designated isozymes I and I1 and isozymes I11 and IV, respectively, in human liver cytosolic fractions. The four forms of biliverdin reductase were purified to homogeneity. There was a 7,80&15,000-fold increase in specific act...
متن کاملCrystal Structure of Biliverdin Reductase
A heme (Fe-porphyrin complex) is a prosthetic group of hemoproteins such as hemoglobin, myoglobin, cytochromes and so on. In biological systems, the heme is decomposed by two enzymes (hemeoxygenase and biliverdin reductase) and excreted (Fig. 1). Biliverdin reductase (BVR) catalyzes the last step of the heme catabolism, in which the biliverdin is reduced into bilirubin with two electrons from N...
متن کاملBiliverdin reductase of guinea pig liver.
The biosynthesis of the heme portion of hemoglobin by animal tissues has been studied extensively (1). In contrast, relatively little is known about the enzymes participating in the initial steps of the pathway for heme catabolism. Thus, the reaction in which heme and globin are separated remains essentially obscure, although it is known that heme undergoes ring cleavage with liberation of carb...
متن کاملBiliverdin reductase: a target for cancer therapy?
Biliverdin reductase (BVR) is a multifunctional protein that is the primary source of the potent antioxidant, bilirubin. BVR regulates activities/functions in the insulin/IGF-1/IRK/PI3K/MAPK pathways. Activation of certain kinases in these pathways is/are hallmark(s) of cancerous cells. The protein is a scaffold/bridge and intracellular transporter of kinases that regulate growth and proliferat...
متن کاملBiliverdin reductase: a major physiologic cytoprotectant.
Bilirubin, an abundant pigment that causes jaundice, has long lacked any clear physiologic role. It arises from enzymatic reduction by biliverdin reductase of biliverdin, a product of heme oxygenase activity. Bilirubin is a potent antioxidant that we show can protect cells from a 10,000-fold excess of H2O2. We report that bilirubin is a major physiologic antioxidant cytoprotectant. Thus, cellul...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Trends in Endocrinology & Metabolism
سال: 2015
ISSN: 1043-2760
DOI: 10.1016/j.tem.2015.02.001